Kinetics of apolipoproteins A-I and A-II

Plasma lipoproteins are a polydisperse collection of particles which range in diameter from 7 to 160 nm. These lipoproteins particles have been classified according to methods of separation 1 . One system, based on density, divides the lipoproteins into five classes: chylomicrons ( ρ < 0.95), very-low-density lipoproteins (VLDL, 0.95 < ρ < 1.006), intermediate-density lipoproteins (IDL, 1.006 < ρ < 1.019), low-density lipoproteins (LDL, 1.019 < ρ < 1.063) and high-density lipoproteins (HDL, 1.063 < ρ < 1.210). Another popular system, based on electrophoretic mobility, divides the lipoproteins into those which remain at the origin (chylomicrons) and those which migrate in the beta region ( β -lipoproteins), pre-beta regions (pre- β -lipoproteins) and alpha region ( α -lipoproteins). There is a partial correspondence of LDL with β -lipoproteins, of VLDL with pre- β -lipoproteins and of HDL with α -lipoproteins. Each lipoprotein is a macromolecular complex of lipids (including triglyceride, cholesterol, cholesterol ester, phospholipid and others) and apolipoproteins (A-I, A-II, A-IV, B, C-I, C-II, C-III, D, E, F, H), arranged such that the lipoprotein particle is relatively soluble in the aqueous plasma environment.