Recovery of Fibrinogen in Fibrinolytic Dogs

Summary Experiments were performed to determine the relative roles of hypofibrinogenemia and split products in fibrinogen replenishment. After fibrinogen depletion, recovery was enhanced when split products were present. Additionally, the presence of split products alone effected a significant increase in fibrinogen concentration without prior depletion; hypofibrinogenemia alone was not as consistent in stimulating replenishment. Perhaps hypofibrinogenemia creates a concentration gradient to favor release of previously stored fibrinogen and reduce storage of newly synthesized fibrinogen. Split products, on the other hand, may increase circulating fibrinogen by competition for available storage sites, facilitation of release from synthesis, or reutilization in synthesis of new fibrinogen.