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Effect of tea on 12-O tetradecanoyl-phorbol-13 acetate (TPA) induced promotion of transformation in JB6 mouse epidermal cells.

Jain Ak, Kayo Shimoi, Yukinori Nakamura, Masakazu Sano, Ikuyoshi Tomita

Abstract

The extract of black and green tea (Camellia sp.) which are widely consumed as commonest beverage, decreased the 12-O-Tetradecanoylphorbol-13 acetate (TPA) induced promotion of transformation in dose dependent manner in JB6 mouse epidermal cell system. The probable mechanisms have been discussed.

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Key concepts: Transformation (genetics), Tetradecanoylphorbol Acetate, 12-O-Tetradecanoylphorbol-13-acetate, Tumor promotion, Phorbol, Phorbol ester, Medicine, Promotion (chess)