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Tumor Promotion by Phorbol Esters in Skin: Evidence for a Memory Effect

Gerhard Fürstenberger, B. Sorg, Friedrich Marks

Abstract

By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.

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Key concepts: Tumor promotion, 12-O-Tetradecanoylphorbol-13-acetate, Promotion (chess), Phorbol ester, Tetradecanoylphorbol Acetate, Epidermis (zoology), Phorbol, Stage (stratigraphy)