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A phase II study of mitoxantrone in advanced breast cancer.

Paolo Pronzato, Andrea Ardizzoni, PierFranco Conte, Marcella Gulisano, Rita Lionetto, Lazzaro Repetto, V. Scornavacche, M. R. Sertoli, Raffaella Rosso

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Abstract

A phase II study with mitoxantrone has been carried out in 30 metastatic breast cancer patients. Of 26 evaluable patients 7 (26.9%) experienced a partial response; 7 (26.9%) patients had stable disease and 12 (46.1%) had progression. Major toxicity observed was: nausea and vomiting in 52% of patients, moderate hair loss in 53% of patients and leukopenia in 53%.

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What this paper is about

A phase II study with mitoxantrone has been carried out in 30 metastatic breast cancer patients. Of 26 evaluable patients 7 (26.9%) experienced a partial response; 7 (26.9%) patients had stable disease and 12 (46.1%) had progression. Major toxicity observed was: nausea and vomiting in 52% of patients, moderate hair loss in 53% of patients and leukopenia in 53%.

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Available abstract

A phase II study with mitoxantrone has been carried out in 30 metastatic breast cancer patients. Of 26 evaluable patients 7 (26.9%) experienced a partial response; 7 (26.9%) patients had stable disease and 12 (46.1%) had progression. Major toxicity observed was: nausea and vomiting in 52% of patients, moderate hair loss in 53% of patients and leukopenia in 53%.

Key concepts: Mitoxantrone, Leukopenia, Nausea, Vomiting, Medicine, Metastatic breast cancer, Breast cancer, Internal medicine

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