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2013•China Journal of Chinese Materia MedicaRequires access

Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound

E Zhang, Rui Tan, Jian Ping Gu, Lili He, Feng Yao

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Abstract

OBJECTIVE: To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. METHOD: The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets. RESULT: Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen. CONCLUSION: Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.

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What this paper is about

OBJECTIVE: To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. METHOD: The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets. RESULT: Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen. CONCLUSION: Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.

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Available abstract

OBJECTIVE: To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. METHOD: The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets. RESULT: Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen. CONCLUSION: Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.

Key concepts: Puerarin, In vitro, Membrane, Drug, Chromatography, Chemistry, Controlled release, Pharmacology

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