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High performance liquid chromatographic analysis of quinolone antibacterial agents.

Francesco Barbato, Patrizia Morrica, Serenella Seccia, Mariacarla Ventriglia

Abstract

Eleven quinolone antibacterials have been analyzed by HPLC. The effects of different pH values and organic modifiers on chromatographic behaviour are discussed. Moreover the influence on separation mechanism of different counter-ions at various concentrations in the eluent has been investigated. Two different chromatographic methods have been selected, that allow the simultaneous analysis of quinolones containing or not a piperazinyl moiety, respectively.

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Available abstract

Key concepts: Chemistry, Quinolone, Chromatography, Antibacterial agent, High-performance liquid chromatography, Moiety, Column chromatography, Antibiotics