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[Study on the expression of HSP70 and HSP90beta in nasopharyngeal carcinoma and the clinical significance].

Tao Liu, Chuanyu Liang, Ling Tian, Yuquan Wei, Jumei Zhao

Abstract

OBJECTIVE: To study the expression of HSP70 and HSP90beta and its clinical significance in human nasopharyngeal carcinoma. METHOD: Immunohistochemical method SP was used to detect the expression of HSP70 and HSP90beta in 50 cases and its clinical significance were studied. RESULT: The positive rate of HSP70 and HSP90beta were 72% and 56% respectively. Analysis of patients, survival demonstrated that the prognosis of NPC with HSP70 (-) and HSP90beta (-) expression were significantly better than the others. CONCLUSION: The overexpression of HSP70 and HSP90beta were probably concerned with the occurrence, development and prognosis of nasopharyngeal carcinoma.

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Key concepts: Nasopharyngeal carcinoma, Clinical significance, Hsp70, Immunohistochemistry, Medicine, Oncology, Internal medicine, Carcinoma