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[Expression of Fas antigen and ligand, placental growth factor in placenta of pregnant women with pre-eclampsia].

Xiu-yun Yue, Xi Zhang, Shihong Cui, Xiuqin Wang

Abstract

OBJECTIVE: To investigate the expression of Fas antigen (Fas) and ligand (FasL), placental growth factor (PlGF) in placenta of pregnant women with pre-eclampsia. METHODS: Expressions of Fas, FasL and PlGF of placenta were determined by immunohistological streptavidin-peroxidase-biotin (SP) method and compared between normal late pregnancy (24 cases) and mild pre-eclampsia (24 cases) and severe pre-eclampsia (24 cases) groups. RESULTS: Different expression of levels Fas, FasL and PlGF were observed in the trophoblasts of most placentae. Positive immunostain of Fas, FasL and PlGF was mainly located in the cytoplasm and membrane of syncytiotrophoblast. FasL and PlGF expressions (63 +/- 4, 81 +/- 6 and 42 +/- 6, 65 +/- 6) were significantly less (P < 0.01), and Fas expression (51 +/- 4, 67 +/- 6) significantly greater in the study subjects compared with controls (P < 0.01). CONCLUSION: Altered expression of Fas and FasL in trophoblasts of placenta may influence pathogenesis or sequelate of pre-eclampsia.

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Key concepts: Fas ligand, Syncytiotrophoblast, Placenta, Placental growth factor, Eclampsia, Medicine, Andrology, Pregnancy