1992•PubMedRequires access
[Psoralen sensitized thermoactivated photodamage to leukocyte membranes].
Kiagova Aa, Ismailova Mi, A Ia Potapenko
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Abstract
Psoralen sensitized photodamage of rat peritoneal exudate cells was investigated. Irradiation of cells induced latent lesions in membranes which during thermal activation at the post-irradiation stage were transformed into permeability channels for trypan blue. The effect linearly increased with fluence of irradiation which indicates one hit production of thermolabile psoralen photoproducts in the membranes.