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2003•Zhejiang Medical JournalRequires access

A study on T-cell subgroup in peripheral blood of children with aplastic anemia

Hua Song

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Abstract

Objective To explore the immunological pathogenesis of aplastic anemia (AA) in children. Methods To determine the CD3+?CD4+?CD8+ T-cell subgroups in peripheral blood of 32 children with aplastic anemia and 20 healthy children by flow cytometer (FCM).Results AA group had higher levels of CD8+ T-cell and a lower ratio of CD4+/CD8+ comparing to the control group (P0.05).Conclusion The increase of CD8+ levels and the decrease of CD4+/CD8+ ratio may be associated with the immunological pathogenesis of aplastic anemia in children.

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What this paper is about

Objective To explore the immunological pathogenesis of aplastic anemia (AA) in children. Methods To determine the CD3+?CD4+?CD8+ T-cell subgroups in peripheral blood of 32 children with aplastic anemia and 20 healthy children by flow cytometer (FCM).Results AA group had higher levels of CD8+ T-cell and a lower ratio of CD4+/CD8+ comparing to the control group (P0.05).Conclusion The increase of CD8+ levels and the decrease of CD4+/CD8+ ratio may be associated with the immunological pathogenesis of aplastic anemia in children.

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Available abstract

Objective To explore the immunological pathogenesis of aplastic anemia (AA) in children. Methods To determine the CD3+?CD4+?CD8+ T-cell subgroups in peripheral blood of 32 children with aplastic anemia and 20 healthy children by flow cytometer (FCM).Results AA group had higher levels of CD8+ T-cell and a lower ratio of CD4+/CD8+ comparing to the control group (P0.05).Conclusion The increase of CD8+ levels and the decrease of CD4+/CD8+ ratio may be associated with the immunological pathogenesis of aplastic anemia in children.

Key concepts: Aplastic anemia, Medicine, Pathogenesis, CD8, Peripheral blood, Anemia, Immunology, CD3

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