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New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads.
Meingassner Jg, H Nesvadba, H Mieth
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Abstract
The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.