2005•Antimicrobial Agents and ChemotherapyOpen access

5-Nitroimidazole Drugs Effective against Metronidazole-Resistant Trichomonas vaginalis and Giardia duodenalis

Jacqueline Upcroft, Linda A. Dunn, Janelle M. Wright, Kamel Benakli, Peter Upcroft, Patrice Vanelle

Abstract

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

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Available abstract

Key concepts: Nitroimidazole, Trichomonas vaginalis, Metronidazole, Giardia, Trichomonas, Antiparasitic, Giardia lamblia, Trichomoniasis