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[Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax].

Bin Yang, Fei Gu, Huijun Li, X.T. Kong, Lei Yu

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Abstract

OBJECTIVE: To explore the mechanism of renal cell carcinoma (RCC). METHOD: We detected the apoptotic status and the expression of apoptotic related gene bcl-2 and bax protein in 48 cases of RCC with TdT-mediated dUTP-biotin nick end labeling (TUNEL) and immunohistochemistry methods. RESULT: 22 cases showed low expression of bcl-2 protein with an average apoptotic index (AI) of 1.35 and 26 cases had high expression of bcl-2 with an AI of 1.04 (P < 0.05). 34 cases showed low expression of bax protein with average AI of 1.03 and 14 cases had high expression of bax protein with an average AI of 1.63 (P < 0.01). The stronger bcl-2 expression, the weaker bax expression and the less number of apoptotic cells. CONCLUSION: both bcl-2 and bax take part in the occurrence and progression of RCC.

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What this paper is about

OBJECTIVE: To explore the mechanism of renal cell carcinoma (RCC). METHOD: We detected the apoptotic status and the expression of apoptotic related gene bcl-2 and bax protein in 48 cases of RCC with TdT-mediated dUTP-biotin nick end labeling (TUNEL) and immunohistochemistry methods. RESULT: 22 cases showed low expression of bcl-2 protein with an average apoptotic index (AI) of 1.35 and 26 cases had high expression of bcl-2 with an AI of 1.04 (P < 0.05). 34 cases showed low expression of bax protein with average AI of 1.03 and 14 cases had high expression of bax protein with an average AI of 1.63 (P < 0.01). The stronger bcl-2 expression, the weaker bax expression and the less number of apoptotic cells. CONCLUSION: both bcl-2 and bax take part in the occurrence and progression of RCC.

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Available abstract

OBJECTIVE: To explore the mechanism of renal cell carcinoma (RCC). METHOD: We detected the apoptotic status and the expression of apoptotic related gene bcl-2 and bax protein in 48 cases of RCC with TdT-mediated dUTP-biotin nick end labeling (TUNEL) and immunohistochemistry methods. RESULT: 22 cases showed low expression of bcl-2 protein with an average apoptotic index (AI) of 1.35 and 26 cases had high expression of bcl-2 with an AI of 1.04 (P < 0.05). 34 cases showed low expression of bax protein with average AI of 1.03 and 14 cases had high expression of bax protein with an average AI of 1.63 (P < 0.01). The stronger bcl-2 expression, the weaker bax expression and the less number of apoptotic cells. CONCLUSION: both bcl-2 and bax take part in the occurrence and progression of RCC.

Key concepts: Apoptosis, TUNEL assay, BAX Protein, Immunohistochemistry, Renal cell carcinoma, Medicine, Gene, Cancer research

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[Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax]. — Research Paper | ScholarLens