The distribution of HPV subtype and multiple HPV infection in cervical cancer and precancerous lesion

Objective：To evaluate the distribution of HPV subtype and multiple HPV infection in cervical cancer and precancerous lesion with HPV DNA chip in Korean women. Methods：We recruited a total of 145 women diagnosed with cervical cancer or cervical intraepithelial neoplasia (CIN), and 404 normal women as control between Dec. 2004 and Sept. 2005. We investigated the distribution of HPV subtype and the multiple infection according to cervical lesion. Results：Of the 145 women, 132 (91.0%) showed HPV infection and 111 (76.6%) showed high risk HPV infection by HPV DNA chip. HPV 16 (48/145, 33.1%) was the most common type, and followed by HPV 58, 18, and 33 in CIN or cervical cancer than control (p＜0.05). Multiple infections were more common in CIN or cervical cancer than control. There was no correlation between the incidence of multiple HPV infection and cervical lesion in young women (＜35 years). In women over 36 years of age, however, multiple infections were the most frequently detected in CIN. Conclusion：The types of HPV 16, 58, 18, 33 were common in cervical precancerous or cancer lesion by order of frequency. Multiple infections were common in women under 35 years of age, and in women with CIN over 36 years of age.