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2009•Journal of China-japan Friendship HospitalRequires access

Expressions of 14-3-3σ in cervical cancer and cervical intraepithelial neoplasia

Bo Xu

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Abstract

Objective:To explore the expressions of 14-3-3σ in cervical cancer and cervical intraepithelial neoplasia(CIN).Methods:The mRNA expression of 14-3-3σ was evaluated by means of real-time fluorogenetic quantitative polymerase chain reaction (RFQ-PCR) in cervical tissues of 28 cervicitis,30 CIN1,30 CIN2,30 CIN3 and 16 cervical cancers.Results:RFQ-PCR showed that the average quantity of 14-3-3σ mRNA in cervical cancer tissues was significantly higher than that in cervicitis tissues(P0.05).While the average quantities of 14-3-3σ mRNA in CINs were similar with cervicitis tissues.Conclusion:14-3-3σ is overexpressed in cervical cancer tissues on transcriptional level,but not in CINs tissues.So 14-3-3σ may play an important role in the pathogenesis of cervical cancer.

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Objective:To explore the expressions of 14-3-3σ in cervical cancer and cervical intraepithelial neoplasia(CIN).Methods:The mRNA expression of 14-3-3σ was evaluated by means of real-time fluorogenetic quantitative polymerase chain reaction (RFQ-PCR) in cervical tissues of 28 cervicitis,30 CIN1,30 CIN2,30 CIN3 and 16 cervical cancers.Results:RFQ-PCR showed that the average quantity of 14-3-3σ mRNA in cervical cancer tissues was significantly higher than that in cervicitis tissues(P0.05).While the average quantities of 14-3-3σ mRNA in CINs were similar with cervicitis tissues.Conclusion:14-3-3σ is overexpressed in cervical cancer tissues on transcriptional level,but not in CINs tissues.So 14-3-3σ may play an important role in the pathogenesis of cervical cancer.

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Available abstract

Objective:To explore the expressions of 14-3-3σ in cervical cancer and cervical intraepithelial neoplasia(CIN).Methods:The mRNA expression of 14-3-3σ was evaluated by means of real-time fluorogenetic quantitative polymerase chain reaction (RFQ-PCR) in cervical tissues of 28 cervicitis,30 CIN1,30 CIN2,30 CIN3 and 16 cervical cancers.Results:RFQ-PCR showed that the average quantity of 14-3-3σ mRNA in cervical cancer tissues was significantly higher than that in cervicitis tissues(P0.05).While the average quantities of 14-3-3σ mRNA in CINs were similar with cervicitis tissues.Conclusion:14-3-3σ is overexpressed in cervical cancer tissues on transcriptional level,but not in CINs tissues.So 14-3-3σ may play an important role in the pathogenesis of cervical cancer.

Key concepts: Cervical cancer, Cervicitis, Cervical intraepithelial neoplasia, Messenger RNA, Real-time polymerase chain reaction, Pathogenesis, Medicine, Polymerase chain reaction

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