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[Synthesis of mono-aldehyde gossypol and its analogues].

Guo Zm, F Wan, Gu Zp, Wu Gp, Peng Sx

Abstract

In an attempt to keep the antispermatogenic activity but lower the toxicity of gossypol by way of structural modification, mono-aldehyde gossypol and four other gossypol analogues have been synthesized. The test of spermicidal activity of these compounds in vitro in 20 seconds showed that mono-aldehyde gossvpol, compound 3, is better than gossvnol.

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Available abstract

Key concepts: Gossypol, Aldehyde, Chemistry, In vitro, Active compound, Toxicity, Stereochemistry, Organic chemistry