2011•PubMedRequires access

[Determination of tetrahydrofuran in urine by headspace solid-phase microextraction and gas chromatography].

Zhihui Han, Fu Sheng, Yu Keping

Abstract

OBJECTIVE: Headspace solid-phase microextraction (HS-SPME) was used pre-concentration procedure for the determination of tetrahydrofuran in urine by gas chromatography with hydrogen flame detector. METHODS: Several parameters controlling SPME was studied and optimised: SPME fiber, extraction time and extraction temperature, desorption time and desorption temperature. RESULTS: Under optimal conditions, the correlation coefficient was 0.9998 and good recoveries (range from 93.0% ∼ 100.8%) were achieved, the detection limit was 0.5 µg/L. CONCLUSION: The method can be applied to the determination of trace amount of tetrahydrofuran in urine.

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Key concepts: Solid-phase microextraction, Chromatography, Tetrahydrofuran, Extraction (chemistry), Gas chromatography, Chemistry, Detection limit, Desorption