[Effect of Ca2+ ions on biosynthesis and component composition of tylosin in Streptomyces fradiae].

The influence of Ca2+ ions on biosynthesis of tylosin complex by Streptomyces fradiae in an enriched medium under submerged conditions was studied. It was shown that Ca2+ (at the concentration of 20 to 30 mM CaCl2) stimulated the tylosin biosynthesis by eliminating the limit of incorporation of the precursors such as macrocin and desmycosin to the process and by inhibiting catabolism of tylosin to relomycin. No potentiation of the Ca2+ influence by effectors of cAMP metabolism i.e. sodium fluoride and papaverin was observed.