2004•Chemistry & BiologyOpen access

Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts

Christopher D. Reeves, Shannon L. Ward, W. Peter Revill, Hideki Suzuki, Matthew A. Marcus, Oleg V. Petrakovsky, Saul Marquez, Hong Fu, Steven D. Dong, Leonard Katz

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Key concepts: Streptomyces fradiae, Tylosin, Polyketide synthase, Polyketide, Streptomyces, Gene cluster, Biology, Hydroxylation