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ChemInform Abstract: pKa and pH Dependence of the Formation of Nitroxide Radicals from Some Drug Substances with an Aliphatic Secondary Amino Group by Oxidation with Hydrogen Peroxide. An ESR Study.

Carl Lagercrantz

Abstract

Abstract It is found that the yields of radicals formed from ephedrine (I), timolol (II), metoprolol (III), and terodiline (IV) are dependent on the pKa value of the parent substance, and consequently on the pH of the reaction mixture since radicals are formed from the free bases only.

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Available abstract

Key concepts: Chemistry, Radical, Hydrogen peroxide, Ephedrine, Nitroxide mediated radical polymerization, Photochemistry, Medicinal chemistry, Timolol