1984•Biochemical JournalOpen access

Selective induction of glutathione S-transferase D in rat testis by phenobarbital

David Sheehan, C M Ryle, Timothy J. Mantle

Abstract

Testis cytosol is shown to contain the Yb2Yb2 -homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A ( Yb1Yb1 ) and C ( Yb1Yb2 ). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.

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Key concepts: Phenobarbital, Glutathione, Cytosol, Glutathione S-transferase, Protein subunit, Transferase, Glutathione transferase, Chemistry