1987•Biochemical JournalOpen access

The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase μ

Janeric Seidegård, Claes Guthenberg, R W Pero, Bengt Mannervik

Abstract

A glutathione transferase from human mononuclear leucocytes with high activity towards trans-stilbene oxide (GT-tSBO) was purified. GT-tSBO is expressed in only about 50% of the individuals studied. As judged from activity measurements, immunological studies and the fact that only those individuals who express glutathione transferase mu have high activity towards trans-stilbene oxide, it is concluded that the hepatic transferase mu is identical with the glutathione transferase (GT-tSBO) in mononuclear leucocytes.

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Key concepts: Transferase, Glutathione S-transferase, Glutathione, Glutathione transferase, Peripheral blood mononuclear cell, Biochemistry, Chemistry, Molecular biology