2004•PubMedRequires access

IL-15 levels in patients with acute hepatic failure.

Chikara Yonekawa, Hajime Nakae, Yajuan Zheng, Hiroshi Wada, Hiroyuki Tanaka, Kimitaka Tajimi

Abstract

Interleukin (IL)-15, an inhibitor of tumor necrosis factor (TNF)-alpha, causes liver injury in mice. We determined levels of IL-15, IL-6, and IL-18 by enzyme-linked immunosorbent assays in 20 patients with acute hepatic failure and examined relationship between these proinflammatory cytokines and IL-15. A significant correlation was observed between the levels of IL-18 and IL-15 (p = 0.0118). IL-15 levels in the nonsurvivors were significantly higher than those in the survivors (p = 0.0357). Our results suggest that IL-15 overexpression may cause liver injury in human.

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Key concepts: Proinflammatory cytokine, Tumor necrosis factor alpha, Medicine, Interleukin, Internal medicine, Interleukin 1β, Gastroenterology, Liver enzyme