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2010•Journal of Shantou University Medical CollegeRequires access

Changes of Tumor Necrosis Factor-α、Interleukin-1、-6 and -8 in Fulminate Acute Pancreatitis of Rats

Shen Wen-lu

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Abstract

Objective: To explore the roles of tumor necrosis factor(TNF)-α,interleukin(IL)-1,-6 and-8 in FAP of rats.Methods: FAP models of rats were established.The changes of TNF-α,IL-1,-6 and-8 in serum were determined at all time points(0,6,12,24,48,72 and 120 hours).PM and dry and wet ratio were analyzed.Results: There was significant difference between two groups on PM and dry and wet ratio from all time points(P0.01).Serum IL-1 increased and peaked at 6 hours,and decreased to normal level gradually.The level of serum TNF-α was bimodal pattern increase.IL-6 and8 both increased and peaked at 24 hours,then decreased to normal level gradually.Conclusion: In rat FAP models,the levels of TNF-α,IL-1(initiator),-6 and-8 increase.

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What this paper is about

Objective: To explore the roles of tumor necrosis factor(TNF)-α,interleukin(IL)-1,-6 and-8 in FAP of rats.Methods: FAP models of rats were established.The changes of TNF-α,IL-1,-6 and-8 in serum were determined at all time points(0,6,12,24,48,72 and 120 hours).PM and dry and wet ratio were analyzed.Results: There was significant difference between two groups on PM and dry and wet ratio from all time points(P0.01).Serum IL-1 increased and peaked at 6 hours,and decreased to normal level gradually.The level of serum TNF-α was bimodal pattern increase.IL-6 and8 both increased and peaked at 24 hours,then decreased to normal level gradually.Conclusion: In rat FAP models,the levels of TNF-α,IL-1(initiator),-6 and-8 increase.

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Available abstract

Objective: To explore the roles of tumor necrosis factor(TNF)-α,interleukin(IL)-1,-6 and-8 in FAP of rats.Methods: FAP models of rats were established.The changes of TNF-α,IL-1,-6 and-8 in serum were determined at all time points(0,6,12,24,48,72 and 120 hours).PM and dry and wet ratio were analyzed.Results: There was significant difference between two groups on PM and dry and wet ratio from all time points(P0.01).Serum IL-1 increased and peaked at 6 hours,and decreased to normal level gradually.The level of serum TNF-α was bimodal pattern increase.IL-6 and8 both increased and peaked at 24 hours,then decreased to normal level gradually.Conclusion: In rat FAP models,the levels of TNF-α,IL-1(initiator),-6 and-8 increase.

Key concepts: Tumor necrosis factor alpha, Tumor necrosis factor α, Acute pancreatitis, Internal medicine, Interleukin 6, Interleukin 1β, Pancreatitis, Endocrinology

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Changes of Tumor Necrosis Factor-α、Interleukin-1、-6 and -8 in Fulminate Acute Pancreatitis of Rats — Research Paper | ScholarLens