Pharmacokinetics study of Albendazole pro-micellesin in landrace pig

OBJECTIVE To study the pharmacokinetic of Albendazole pro- micelles in landrace pig. METHODS Plasma concentration of Albendazole,Albendazole sulfoxide,Albendazole sulfone were determined by RP- HPLC,mebendazole as internal standard,after oral administration of suspension of Albendazole tablets saline solution and Albendazole pro- micelles hydration solution,and calculate pharmacokinetics parameter. RESULTS The concentration- time cure of Albendazole pro- micelles and Albendazole tablets were fitted to a two- compartment model and these main pharmacokinetic parameters obtained showed statistical significance.The relative bioavailability of Albendazole pro- micelles compared with tablet by oral administration were 230. 45%. CONCLUSION Albendazole pro- micelles,with longer residence time in gastrointestine and low clearance rate,could increase the gastrointestinal absorption,prolong the residence time of Albendazole sulfoxide and sulfone in the blood after oral administration,so it could improves the bioavailability.