The application of sequential invasive-noninvasive mechanical ventilation in chronic obstructive pulmonary disease (COPD) with acute respiratory failure (ARF)

Objective To investigate the therapeutic effects of chronic obstructive pulmonary disease (COPD) with acute respiratory failure using sequential invasive-noninvasive mechanical ventilation. Methods 24 COPD patients with ARF were divided into two groups, each group having 12 cases. The therapy group was treated with sequential invasive-noninvasive mechanical ventilation, and the contrast group was treated with invasive mechanical ventilation. The two groups were compared on the measures of progress of the disease, of blood gas analysis, of number of ventilators-associated pneumonia (VAP), of deaths, and duration of mechanical ventilation. Results Compared with the contrast group, the therapy group had lower rate of VAP (0/12, 4/12,P0.05), shorter duration of total mechanical ventilation [(12.2±6.2)d, (22.4±15.3) d,P0.05],and fewer days in hospital [(15±7) d, (18±14) d,P0.05]. Conclusion Using properly while changing invasive mechanical ventilation into sequential invasive-noninvasive mechanical ventilation, the VAP rate of COPD with ARF can be shortened, the duration of mechanical ventilation and in hospital stay can be shortened, and the therapeutic effects can be improved obviously.