EXPRESSION AND CLINICAL SIGNIFICANCE OF Cyclin D_1 IN BREAST CANCER

Objective To investigate the expression of cyclin D1 in breast cancer and to evaluate its clinical significance in predicting its prognosis. Methods Cyclin D1 was measured in 78 cases of breast cancer tissues and 37 cases of benign disease by immunohistochemistry SP method.The results were analyzed and compared. Results The positive rate of cyclin D1 in breast cancer in different pathologic stages was 47.62%(G1),61.76%(G2) and 17.39%(G3),respectively.In benign disease,it was 6/17(35.29%,atypical ductal hyperplasia) and 1/20(5.00%,common breast disease).The difference was significant between the cancer and benign one.The expression of cyclin D1 in the cancer was significantly higher than that in benign disease(χ2=7.291,P0.01).Their expression was related to pathologic stage(χ2=11.008,P0.01).Analysis of the relationship of cyclin D1 and estrogen receptor(ER) showed that the positive rate of cyclin D1 in ER(+) tissue was higher than ER(-) tissue(χ2=4.019,P0.05).The difference between the groups of Cyclin D1(+) ER(+) and cyclin D1(+) ER(-) was significant(χ2=4.501,P0.01). Conclusion Overexpression of cyclin D1 plays an important role in the differentiation and development of cancer.The expression of cyclin D1 in breast cancer is related to pathologic stages.The high expression of cyclin D1 protein and positive expression of ER is highly identical in breast cancer. Overexpression of cyclin D1 predicts poor prognosis in ER-negative patients and good prognosis in ER-positive.