Detection the relationship between expression of CYCLIN D1 and p53 clinicalpathological characteristics and prognostic significance in ER/PR-negative breast cancer

Objective To investigate the expression of Cyclin D1 and p53 and their correlation with the clinicalpathological features and prognosis of ER/PR-negative breast cancer.Methods We performed immunohistochemical to detect Cyclin D1 expression on breast cancer tissue microarray including 96 ER-negative breast cancer tissues.Results The expression of Cyclin D1 is located nuclear,the expression rates were: high expression of 19(19.8%),low expression of 60(62.5%),negative 17(17.7%).Cyclin D1 high expression rates in poor prognostic group was significantly higher than good prognostic group(31.7% versus 10.9%,P= 0.011),and Cyclin D1 high expression rates in metastatic group was significantly higher than that of the non-metastatic group(30.6% vs.8.9%,P= 0.009) The expression of cyclin p53 is located nuclear,the expression rates were: positive 62(64.6%),negative 34(35.4%).Conclusions Higher expression of Cyclin D1 significant correlated with ER/PR-negative breast cancer poor prognosis and lymph node metastasis.More advantages compared with p53 in the prognosis of breast cancer patients,Cyclin D1 could be the indicator to measure the patient's prognosis.