Analysis on the results of the baseline survey of drug resistance of tuberculosis in Wuhan City

Objective To understand the epidemic status and characteristics of M.Tuberculosis drug resistance patterns in Wuhan city,so as to provide evidence for evaluating and improving TB control program.Methods Registry records between March and August of 2008 were collected,all new smear positive and newly registered retreatment smear positive patients were included for survey,questionnaires,patients' clinical data were collected;The proportional method was applied,6 drugs:Isoniazid,Rifampicin,Ethambutol,Streptomycin,Kanamycin,Ofloxacin were subjected to DST test(drug susceptibility test).939 cases of smear positive were included,through serotype identification,885 cases were M.Tuberculosis(Mtb).Results Among 885 cases of MTB,the overall rate of drug resistance was 22.4%(198/885),and ratefor mono-drug was 9.7%(86/885),6.1%(54/885)、MDR-TB 6.2%(55/885)for poly-resistance was 6.1%(54/885),for multi-resistance was 6.2%(55/885) and extensive drug resistance was 0.3%(3/885).The same rates for new smear positive patients were 9.0%(62/688),4.5%(31/688),4.2%(29/688) and 0.3%(2/688) respectively.Resistance rates for retreatment smear positive patients were 12.2%(24/197),11.7%(23/197),13.2%(26/197) and 0.5%(1/197)respectively.Of all the 6 drugs tested for drug susceptibility,29 resistance patterns were recognized,of which,5 patterns were of mono-resistance,13 patterns were of poly resistance,11 patterns were of multi-drug resistance(including extensive drug resistance). ConclusionBaseline data and characteristics of TB drug resistance were for the first time obtained in Wuhan city.The TB drug resistance rates in wuahn city was below the national average,however,still facing the threat of MDR-TB and XDR-TB.The control of drug-resistant TB epidemic has become an important part of tuberculosis control program in Wuhan city.