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2010•Acta Academiae Medicinae Qingdao UniversitatisRequires access

EXPRESSIONS OF EGFR AND NF-κB p65 PROTEINS AND THEIR SIGNIFICANCE IN NON-SMALL CELL LUNG CANCER

Xinlan Zhou

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Abstract

Objective To study the expressions of EGFR and NF-κB p65 in NSCLC and their correlation with the clinicopathologic features. Methods Three-step immunohistochemistry was used to detect the expressions of EGFR and NF-κB p65 in 63 cases of NSCLC and 20 of normal lung tissue. Results The expressions of EGFR and NF-κB p65 in the cancer were significantly higher than that in nomal lung tissue(χ2=17.24,28.61;P0.05).The expressions were associated with tumor differentiation,TNM staging,and whether or not with lymph node metastasis(Z=-2.920——2.292,P0.05),but not related to gender,age and type of pathology(P0.05). Conclusion The overexpressions of EGFR and NF-κB are related to the occurrence,cell proliferation,infiltration and metastasis of NSCLC,which can be used as an index to predict the prognosis and a new target of molecular therapy for this disease.

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What this paper is about

Objective To study the expressions of EGFR and NF-κB p65 in NSCLC and their correlation with the clinicopathologic features. Methods Three-step immunohistochemistry was used to detect the expressions of EGFR and NF-κB p65 in 63 cases of NSCLC and 20 of normal lung tissue. Results The expressions of EGFR and NF-κB p65 in the cancer were significantly higher than that in nomal lung tissue(χ2=17.24,28.61;P0.05).The expressions were associated with tumor differentiation,TNM staging,and whether or not with lymph node metastasis(Z=-2.920——2.292,P0.05),but not related to gender,age and type of pathology(P0.05). Conclusion The overexpressions of EGFR and NF-κB are related to the occurrence,cell proliferation,infiltration and metastasis of NSCLC,which can be used as an index to predict the prognosis and a new target of molecular therapy for this disease.

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Available abstract

Objective To study the expressions of EGFR and NF-κB p65 in NSCLC and their correlation with the clinicopathologic features. Methods Three-step immunohistochemistry was used to detect the expressions of EGFR and NF-κB p65 in 63 cases of NSCLC and 20 of normal lung tissue. Results The expressions of EGFR and NF-κB p65 in the cancer were significantly higher than that in nomal lung tissue(χ2=17.24,28.61;P0.05).The expressions were associated with tumor differentiation,TNM staging,and whether or not with lymph node metastasis(Z=-2.920——2.292,P0.05),but not related to gender,age and type of pathology(P0.05). Conclusion The overexpressions of EGFR and NF-κB are related to the occurrence,cell proliferation,infiltration and metastasis of NSCLC,which can be used as an index to predict the prognosis and a new target of molecular therapy for this disease.

Key concepts: Immunohistochemistry, Lung cancer, Medicine, Lymph node metastasis, NF-κB, Pathology, Oncology, Infiltration (HVAC)

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