Protein expressions of EGFR in non-small cell lung cancer

Objective: To detect the expressions of related proteins EGFR with PI3K /AKT pathway in non-small cell lung cancer( NSCLC),and explore the relationship of its and clinical pathologic features of NSCLC. Methods: Immunohistochemistry Maxvision two-step method was used to examine the expressions of EGFR in NSCLC and normal lung tissue. At the same time,the SPSS17. 0 software was used for the statistical analysis. Results: The positive expression rates of EGFR protein were 68. 4%( 54 /79) and 27. 3%( 3 /11) in NSCLC and normal lung tissue( P 0. 05). In the NSCLC,the over expression of EGFR was not related with gender,metastasis of lymph nodes and pathological type,but it was related with the differentiation extent( P 0. 05). Conclusion: The expression of EGFR in NSCLC is higher than that in the normal lung tissue,and it has relation with the differentiation extent,which shows that EGFR may promote the occurrence and development of NSCLC. So the detection of the expression of this factor can guide the diagnosis and treatment of NSCLC.