Clinical Results of Regimen Based on Oxaliplatin in Chemotherapy for 76 Patients With Advanced Gastric Cancer

Objective To evaluate the response and toxicity of Oxaliplatin(L-OHP) combined with leucovorin (LV) and 5-fluorouracil(5-Fu) regimen for patients with advanced gastric cancer,and compare with traditional chemotherapy regimen.Methods Seventy-six patients with advanced gastric cancer were divided into treatment group(group A) forty patients and control group(group B)thirty-six patients using non-randomized method.The regimen of the group A was L-OHP 130 mg/m2,iv infusion for 3～4 hours on day 1; LV 200 mg/m2,iv infusion for 2 hours followed by 5-Fu 400 mg/m2,iv infusion for 6 hours from day 1 to 5.The regimen of the group B was DDP 15 mg/m2,iv infusion from day 1 to 5;VP-16 75 mg/m2,iv infusion from day 1 to 3; the usage of LV and 5-Fu were similar to the group A.All patients were evaluated after 2 cycles (every cycle lasted 21 days).Results The response rate was 55.0%(22/40) in group A and 33.33%(12/36) in group B.The statistic difference was seen in two groups(P 0.05). The median survival time and 1-year survival rate were 10 months and 42.5%(17/40) for group A versus 8.5 months and 36.1% (13/36)for group B.There were no statistic difference in two groups(P0.05).The median time to progression was 7.5 months in group A and 5.3 months in group B(P0.05).The main toxicities were neuro-sensory toxicity in group A and vomiting and leucopenia in group B.There were significant statistically difference in twogroups (P0.01).Conclusion Oxaliplatin combined with LV/5-Fu regimen is high response and well tolerable for advanced gastric cancer,which can be practiced safely.