Effect of enteral nutrition on nutrition status,immune function and prognosis of patients after surgery for gastroenteric cancer

Objective To compare the clinical effects of early enteral and parenteral nutrition,and to study their effects on nutritional status,immune function and prognosis in early postoperative patients with gastrointestinal cancer.Methods 70 patients with gastrointestinal cancer were randomly divided into early postoperative enteral nutrition group 19 cases(the experimental group)and parenteral nutrition group 17 cases(the control group).The control group was treated with parenteral nutrition support,and observation group was treated with early enteral nutrition therapy.The nutrition status of the patients was detected before and after operation.Results(1)The weight of patients had not significant difference before the surgery.After operation,the levels of the body weight,serum albumin and prealbumin in patients were higher than those in the control group[(57.6±11.37)kg vs.(54.7±8.64)kg,(36.7±10.58)g/L vs.(34.2±9.04)g/L,(26.01±7.13)g/L vs.(22.27±6.35)g/L,P0.05].(2)Compare to the control group,intestinal peristalsis recovery time,the first time anal exsufflation time and hospital stay were short in the experimental group[(3.7±1.8)d vs.(4.6±1.2)d,(4.2±1.5)d vs.(5.9±2.1)d,(10.3±2.8)d vs.(14.1±4.7)d,P0.05].There are significant differences(P0.05).(3)After operation,total number of lymphocytes,CD3+,CD4+,CD8+ cell and CD4+/CD8+ ratio in patients reduced.There was vary degrees by nutritional support and recovery,the experimental group more visible[(1.28±0.54)×109/L vs.(1.17±0.41)×109/L,(59.61±9.67)% vs.(57.23±10.59)%,(33.16±8.32)% vs.(2.21±9.39)%,(26.10±4.93)% vs.(23.12±4.75)%,1.46±0.74 vs.1.42±0.54,P0.05].There were significant differences(P0.05).(4)The incidence of complications had no significant differences in two groups(P0.05).Conclusions Compared with parenteral nutrition support,enteral nutrition support can efficiently ameliorate the nutrition state of the post-operative patients,and improve the gut barrier function and increase immunity of the post-operative patients.