Changes of pregnancy-associated plasma protein-A and C-reactive protein in acute coronary syndrome patients

Objective This study is aimed to investigate the changes and the relations of PAPP-A and hs-CRP in acute coronary syndrome patients. Methods Sixty-eight patients with coronary artery disease who were documented by angiography, 43 cases with acute coronary syndrome(ACS), 25 cases with stable angina(SAP), 20 normal healthy control ,all the patients' plasma was analysed for PAPP-A and hs-CRP with enzyme- linked immunosorbent assay (ELISA) and untrasensitive immunoassay respectively. Results PAPP-A and hs-CRP were higher in ACS group [PAPP-A: (17.9±8.7)mIU/L;hs-CRP: (4.31±0.38)mg/L] compared with normal healthy control group [PAPP-A: (7.1±4.2)mIU/L, hs-CRP: (2.01±0.14)mg/L,P0.01]。PAPP-A and hs-CRP were significantly elevated in acute coronary syndrome patients than in stable angina patients [PAPP-A: ( 17.9±8.7)mIu/L VS (8.5±5.6)mIu/L, P0.01;hs-CRP:(4.31±0.38)mg/L VS (2.13±0.28)mg/L, P0.05 respectively]. hs-CRP level was positively correlated with PAPP-A (r=0.68, P0.01). Conclusion PAPP-A and hs-CRP are elevated in acute coronary syndrome group and can be used as markers of acute coronary syndrome.The positive correlation between PAPP-A and hs-CRP were found in this study.