The expression and clinical significance of hs-CRP,IL-12 and IL-18 in serum of patients with coronary heart disease

Objective To detect the expression of hs-CRP,IL-12 and IL-18 in serum of patients with coronary heart disease,and explore their clinical significance.Methods 100 cases of patients with coronary heart disease in our hospital were selected as the observation group.60 healthy persons were taken as control group,and the expression differences of hs-CRP(detected by Immunoturbidimetric assay),IL-12 and IL-18(detected by enzyme-linked immunosorbent assay) were analyzed.Results hs-CRP,IL-12 and IL-18 expression level of observation group was significantly higher than those of control group,and correlated with coronary heart disease types and coronary artery lesion number.The linear correlation analysis showed that hs-CRP,IL-12,IL-18 expression of the patients with coronary heart disease was positive correlation.Conclusion The level of hs-CRP,IL-12 and IL-18 shows high expression in serum of patients with coronary heart disease,three indexes have promotion effect on occurrence and development of coronary heart disease,the combined detection of three indexes is important to early determine the degree of coronary heart disease.