Expression of CD44V6 in Gastric Carcinoma and Is Significance

Objective: To explore the expression and clinical significance of CD44V6 in gastric carcinoma and to investigate its relationship with biological behavior. Methods: Two stages immunohistochemical method was used to examine the expression of CD44V6 in 120 cases gastric carcinoma,20 cases normal tissue and 26cases atypital hyperplasia tissue. Results: The positive rates of CD44V6was 72.5%(87/120)in gastric carcinoma,not observed in normal tissue and the focally expression of CD44V6 only in the atypical hyperplasia of the gastric basal cell.The higher the expressions of CD44V6 were the worse the pathological grade became.The positive rates of CD44V6 in different pathological grades of the gastric carcinoma was 33.3%in grade 1,65.4% in grade 2 and 80.7% in grade 3(P0.05). The higher the expressions of CD44V6 were, the worse the clinical stage was. But,there were no significant difference in all ground(P0.05).The positive-staining of CD44V6 in lymphatic metastasis(89.1%) was higher than that in no lymphatic metastasis(46.4%)(P0.05). Conclussion: CD44V6 was positively correlated with the development,progression and metastasis of gastric cancer and could be used as a marker to evaluate prognosis of gastric carcinoma,and it would be worth in choosing a combined modality therapy.