Dynamic observation on development of Trichinella spiralis larvae and reaction of inflammatory cells in mice

Objective To observe the inflammatory cells and distribution of T.spiralis larvae in mice infected by T.spiralis. Methods The mise were devided into three groups at vandom and infected with certain numbers of T.spiralis larvae.21、28、35、42 days later,the mice were anatomized respectively and the development,distribution and density of the larvae in the mouse bodies were observed and peripheral blood cells were counted. Results The development of larvae wase about the same in the three groups.The muscles harbouring the highest number of larvae were masseter and diaphragm muscle.However,the distribution and density of the larvae were significantly different.Neutrophilic granulocyte and lymphocyte proportion began to rise from14 days after infection later and reached the peak at 21 and 28 days later respectively. Conclusion The results indicate that infection with a small numbers of larvae is fit for keeping species.The variation tendency of inflammatory cell proportion may be related to immune change in infected mouse.