Effects of remifentanil on tracheal extubation in the patient undergoing superficial surgery

Objective To observe the efficacy of remifentanil on the hemodynamics and recovery during tracheal extubation.Methods Eighty patients, ASA Ⅰor Ⅱ, scheduled for breast or thyroid operation, were randomly divided into four groups. The infusion rates of remifentanil were reduced to 0(group C), 0.01(group R1), 0.03(group R2), and 0.05(group R3)μg·kg-1·min-1 respectively in the recovery period. Hemodynamics, trachea tube tolerance and VAS score were observed before the end of operation (T1), during trachea suction (T2) and extubation (T3).Results Compared with T1, SBP, DBP, and HR increased in all groups at T2(P0.05). Compared with group C, SBP, DBP and HR decreased in groups R1,R2 and R3 at T2 and T3 (P0.05), and the recovery of respiratory, eyes opening and extubation time were all prolonged in groups R1, R2 and R3.Conclusion Continuous infusion of remifentanil at 0.01-0.03 μg·kg-1·min-1 can effectively prevent hemodynamic reaction to extubation in patients undergoing TIVA anesthesia with a mild respiratory depression.