2005•Jilin Nongye Daxue xuebaoRequires access

Corroboration of Ciprofloxacin Resistance of Staphylococcus aureus When Mediated by Efflux Pump

Yu Lu

Abstract

Abstrcat Resistance against ciprofloxacin was induced in 1 Staphylococcus aureus control strain ATCC25923 and 3 clinical isolates by 1/2 MIC, and minimal inhibitory concentration(MIC) of ciprofloxacin against Staphylococcus aureus was determined with disk diffusion and agar dilution susceptibility tests. Intaking of ciprofloxacin was detected by improved CCCP-fluorospectrophotometry in Staphylococcus aureus strains and their induced resistant strains. CCCP did make the intaking of ciprofloxacin higher in all strains. This corroborated the existance of ciprofloxacin resistance when mediated by efflux pump in Staphylococcus aureus. After reaching concentrations of steady state, dose of intaking of ciprofloxacin in strong resistant isolates is lower than that of weak resistant isolates.

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Key concepts: Ciprofloxacin, Staphylococcus aureus, Efflux, Microbiology, Agar dilution, Agar Dilution Method, Minimum inhibitory concentration, Staphylococcus