2001•Unpublished venueRequires access
Effects of acetoside on improving the ability of learning and memory in mice
Piao Jing
Open publisher page 0 citations
Abstract
AIM To investigate the effect of acetoside on the ability of learning and memory in mice. METHODS The dysmnesia model of acquired learning induced by scopolamine was used. The ability of learning and memory was measured by step through task and water maze task. The activity of acetylcholinesterase and M cholinergic receptors were determined. RESULTS Acetoside increased the retention latencies and decreased the number of avoidance response errors in step through task( P 0 05). In the water maze task, acetoside increased the correct percentage( P 0 05). Acetoside antagonized the increase of acetylcholinesterase and the decrease of Bmax of M cholinergic binding sites induced by scopolamine ( P 0 05). CONCLUSION Acetoside improves the disability of learning and memory induced by scopolamine, and its effect may be involved in the activity of the acetycholine system.