Comparison of sufentanil with fentanyl in patient-controlled intravenous analgesia after gynecological surgery

Objective To compare the clinical efficacy and safety of sufentanil with fentanyl in patient-controlled intravenous analgesia(PCIA)after gynecological surgery.Methods Forty fe- male patients,ASAⅠ～Ⅱ,scheduled for gynecological surgery and requiring PCIA,were ran- domly allocated to one of the following two groups:patients in groups fentanyl and sufentanil were received fentanyl 0.2μg·kg~(-1)·h~(-1) and sufentanil 0.02μg·kg~(-1)·h~(-1) respectively.Visual analogue scale(VAS,0～10)and sedation scores were recorded at 2,4,8,12,24,48 h after PCIA.The changes of circulation and respiration,times of PCA,supplementary analgesics,side effects and the patients' satisfactory degree were observed.Results Compared with fentanyl group,VAS and se- dation scores in group sufentanil at each point in 48 hours were no statistical differences.The times of PCA was lower in group sufentanil compared with group fentanyl(P0.05).During PCIA, there was no respiratory depression and pruritus happened.The incidences of nausea,vomiting in two groups were no significant differences.Conclusion PICA with sufentanil after gynecological surgery is more effective and safe compared with fentanyl.