Comparation of Sufentanil and Fentanyl for Patient-controlled Intravenous Analgesia After Gynaecologic Surgery

Objective To compare the efficacy and side-effects of sufentanil with fentanyl at equivalent dose for postoperative patient-controlled intravenous analgesia(PCIA) after gynecologic surgery.Methods The total of 400 patients undergoing gynecologic surgery were recruited in this randomized double blind study to receive either intravenous sufentanil at 0.5 μg·mL-1(group SF) or fentanyl at 5μg·mL-1(group F) for PCIA.Pain intensity according to visual analogue score(VAS),PCA opioid consumption as well as pressing frequency,sedative scores and side-effects from 0 to 4 h,4 to 12 h,12 to 24 h after administration were recorded.Results Both the VAS scores at rest and motion were fewer in group SF than in group F from 0 to 4 h,4 to 12 h after surgery(P0.05).The PCIA pressing frequency within 24 h after surgery was lower in group SF than those in group F(P0.05).The incidences of respiratory depression as well as nausea and vomiting in group SF were lower than those of group S(P0.05).The degree of variation of PCIA opioid consumption in group SF was lower than group S.Conclusion With a lower incidence of side-effects,PCIA with sufentanil can provide better postoperative analgesic efficacy than fentanyl after gynecologic surgery.And the inter-individual variant degree of sufentanil consumption is lower than that of fentanyl.