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2011•Xiandai shengwu yixue jinzhanRequires access

Expression and significance of p27kip1 and PCNA in human brain astrocytomas

Lifeng Wang

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Abstract

Objective:To detect the expression of the p27kip1 and proliferating cell nuclear antigen(PCNA)in human brain astrocytomas and relationship with the pathology grade and discuss the value of p27kip1 in astrocytoma development.Methods:SP immunohistochemical analysis was used for detection the expression of p27kip1 and PCNA in 64 astrocytomas.Results:The percents of p27kip1 positive labeling cells decreased along with the growing of pathology grade in human astrocytomas.However,PCNA was on the contrary,a significant negative correlation is observed between the p27kip1 and PCNA.Conclusion:The decreased p27kip1 protein expression might play an important role in the genesis and development of human brain astrocytomas,immuohistochemical analysis of PCNA might be useful in deciding the grade of malignant of astrocytoma.

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What this paper is about

Objective:To detect the expression of the p27kip1 and proliferating cell nuclear antigen(PCNA)in human brain astrocytomas and relationship with the pathology grade and discuss the value of p27kip1 in astrocytoma development.Methods:SP immunohistochemical analysis was used for detection the expression of p27kip1 and PCNA in 64 astrocytomas.Results:The percents of p27kip1 positive labeling cells decreased along with the growing of pathology grade in human astrocytomas.However,PCNA was on the contrary,a significant negative correlation is observed between the p27kip1 and PCNA.Conclusion:The decreased p27kip1 protein expression might play an important role in the genesis and development of human brain astrocytomas,immuohistochemical analysis of PCNA might be useful in deciding the grade of malignant of astrocytoma.

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Available abstract

Objective:To detect the expression of the p27kip1 and proliferating cell nuclear antigen(PCNA)in human brain astrocytomas and relationship with the pathology grade and discuss the value of p27kip1 in astrocytoma development.Methods:SP immunohistochemical analysis was used for detection the expression of p27kip1 and PCNA in 64 astrocytomas.Results:The percents of p27kip1 positive labeling cells decreased along with the growing of pathology grade in human astrocytomas.However,PCNA was on the contrary,a significant negative correlation is observed between the p27kip1 and PCNA.Conclusion:The decreased p27kip1 protein expression might play an important role in the genesis and development of human brain astrocytomas,immuohistochemical analysis of PCNA might be useful in deciding the grade of malignant of astrocytoma.

Key concepts: Proliferating cell nuclear antigen, Astrocytoma, Immunohistochemistry, Pathology, Human brain, Biology, Glioma, Medicine

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Expression and significance of p27kip1 and PCNA in human brain astrocytomas — Research Paper | ScholarLens