Effect of ketamine on inflammatory factors and oxygen free radical during one lung ventilation in man

Objective To observe the effects of ketamine on inflammatory factors and oxygen free radical in patients during one lung ventilation(OLV).Methods Twenty-four patients with lung cancer undergoing lung resection were randomly divided into two groups with 12 cases each:ketamine(group K)and control(group C).Blood samples were taken after induction of anesthesia(T1,baseline),at OLV 45 min(T2),OLV 90 min(T3),and 2 h after operation(T4)for determination of serum TNF-α,IL-6,IL-8,IL-10,SOD and MDA concentrations.Results Serum TNF-α,IL-6 and IL-8 concentrations were all significantly increased at T2(P0.05)and Serum IL-10 was increased at T3(P0.05).Serum TNF-α,IL-6 and IL-8 concentrations were lower at T3,T4 and IL-10 was higher in group K than those in group C(P0.05).Serum MDA concentration was significantly higher at T3,T4(P0.05)than T1 in both groups,and was lower at T3,T4 in group K than in group C(P0.05).Serum SOD concentration was significantly lower at T3,T4(P0.05)than T1 in both groups,and was higher at T3,T4 in group K than in group C(P0.05).Conclusion Ketamine could alleviate the inflammatory reactions of pulmonary during OLV.