Variation of plasma C-reactive protein levels and serum cardiac troponin I before and after PCI in patients with unstable angina pectoris and its predictive value for prognosis

Objective To study variation of plasma C-reative protein(CRP)levels and serum cardiac troponin I(cTnI)before and after percutaneous coronary intervention(PCI)in unstable angina pectoris(UAP)patients,and explore its prognostic predictive value.Methods The plasma CRP levels and cTnI levels of 87 patients were measured before PCI,immediately after as well as 1 h,12 h,24 h and 48 h later.The patients were separated into 2 groups according to CRP and cTnI levels,Group A(high level):CRP3 mg/L,and CTnI2.0 μg/L,n=65 cases;Group B(low level):CRP3 mg/L or CTnI2.0 μg/L,n=22 cases.Then we analysed the plasma CRP and(cTnI)levels with the severity extent of coronary,the number,pressure and time of balloon angioplasty,the number of stents and complications.We followed up for 12 months and accounted the rate of acute cardiac events.Results The levels of CRP,cTnI were significantly higher in all patients after PCI(P0.05);the CRP and cTnI levels had positive correlation with the severity extent of coronary,the number,pressure,and time of balloon angioplasty,the number of stents and complications.The rate of acute cardiac events of Group A was obviously higher than that of Group B(P0.05).Conclusion Lesions in inflammatory response with PCI might affect the prognosis of unstable angina pectoris(UAP)patients,and the levels of CRP and cTnI might have clinical predictive value.