The clinical observation of Milrinone in chronic heart failure acute exacerbation

Objective To observe the clinical curative effect of Milrinone in chronic heart failure acute exacerbation period.Methods Ninety-two patients with chronic heart failure were randomly divided into two groups,A group with routine treatment such as digitalis,ACEI,diuretics and lipid nitrate drugs.On the basis of the A group,B group was given intravenous infusion of Milrinone and then it was observed for 2 weeks.Two groups were compared in left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVDd),heart rate,blood pressure,NYHA classification of clinical changes in heart function and adverse drug reactions.Results After 2 weeks of treatment,both groups had significantly improved heart function after treatment,the difference was significant(P0.05).Compared with A group,heart rate,blood pressure,and LVDd of patients in B group decreased,and LVEF increased(P0.05).Conclusion Milrinone has significant clinical efficacy and safety in acute exacerbation of chronic heart failure.