Serum cytokines in patients with multiple organ failure following open-heart-surgery

AIM To evaluate the clinical significance of the changes in serum tumor necrosis factor-α (TNF-α), interleukin-β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8). METHODS Thirteen patients with multiple organ failure following openheartsurgery were selected. Serum TNFα, IL1β, IL6, IL8 levels were measured by enzymelinked immunosorbent assay (ELISA). RESULTS The levels of plasma TNFα (0.61±0.08), (0.81±0.09) vs (0.20±0.05) μg·L -1 (p0.05, 0.01); IL1β (0.52±0.09), (0.69±0.04) vs (0.16±0.03) μg·L -1 (P0.01, 0.01); IL6 (0.41± 0.08 ), (0.56±0.07) vs (0.17±0.03) μg·L -1 (P0.05,0.05); IL8 (3.70±0.80), (4.92±0.78) vs (1.6±0.40) μg·L -1 (P0.05, 0.05) rose markedly after MOF. The time of reaching the peak value in IL6, IL8 was slower than that in TNFα, IL1β. CONCLUSION The abnormal release of the cellular factors is an important cause of MOF after openheartsurgery. TNFα,IL1β are triggling factors.