A Clinical Trial of Rabeprazole in the Treatment of Duodenal Ulcer

Objective To evaluate the effect and safety of Rabeprazole on patients with duodenal ulcer.Methods Patients with duodenal ulcer in active phase were randomly divided into group A(rabeprazole 10 mg/d) and group B(omeprozole 20 mg/d).After 4 weeks treatment,the curative effect was detected by gastroscope and the side-effect was observed.Results After weeks of treatment,the healing rate of ulcer and total effective ratio in group A were 95.0% and 99.0%,and in group B,they were 93.6% and 98.9%.There were no significance between group A and B(P0.05).But the disappear rate of bellyache in group A was higher than that in group B(P0.05).After 1 day treatment,in group A,33.0% patients' bellyache disappeared,but in group B,it's 18.8%.Conclusions The effects of rabeprazole and Omeprazole for duodenal ulcer is satisfactory.Rabeprazole is more effective cure for remitting abdominal pain and have little side-effect.