A Molecular Epidemiological Study on the Relationship between Glutathione S-Transferase M1,T1 Genetic Polymorphism and Susceptibility to Gastric Cancer

Objective In order to examine the relationship between glutathione s transferase M1,T1(GSTM1,GSTT1)genetic polymorphism and susceptibility to gastric cancer.Mehtods A case control study was carried out and polymerase chain reaction (PCR)technique was used to identify GSTM1,GSTT1 genotype in 89 cases of primary gastric cancer and 94 controls.Results The frequency of GSTM1 null genotype in patients with gastric cancer(61 8%)showed a statistically significant increase compared to the control group frequency (46 8%)(χ 2=4.14,P=0 042,OR=1 84,95%CI=1 02～3 31);the frequency of GSTT1 null genotype in cased (57 3%) was also higher than it in controls,but this increase did not reach statistical significance (χ 2=1 28,P=0 257,OR=1 40,95% CI=0 78～2 51);the risk for gastric cancer in those with GSTM1 nun and GSTT1 null genotype was significantly higher than that in those with GSTM1 non null and GSTT1 non null genotype,with the OR of 2.27 and 95% CI of ORs 1 06～4 85;the risk for gastric cancer in those smoking with GSTM1 null genotype increased significantly (OR=3 09,95%CI=1 33～7 19).Conclusion GSTM1 null genotype is associated with the risk for gastric cancer;the individuals with GSTM1(-) and GSTT1(-) are more susceptibility to gastric cancer;GSTM1 and smoke may cooperate with each other in the occurrence and development of gastric cancer.